Retinal Thickness Changes Over Time in a Murine AD Model APPNL-F/NL-F

Background: Alzheimer's disease (AD) may present retinal changes before brain pathology, suggesting the retina as an accessible biomarker of AD. The work is a diachronic study using spectral domain optical coherence tomography (SD-OCT) to determine total thickness and nerve fiber layer (RNFL) in APP NL−F/NL−F mouse model AD at 6, 9, 12, 15, 17, 20 months old compared wild type (WT) animals. Methods: Total RNFL were determined. mean was analyzed following Early Treatment Diabetic Retinopathy Study sectors. measured six sectors axonal ring scans around optic nerve. Results: In group WT animals, observed following: (i) At 6-months-old, significant thinning outer temporal sector observed; (ii) 15-months-old inner inferior noticed; (iii) 17-months-old, thickening nasal found both rings; (iv) 20-months-old, nasal, temporal, superior seen. thickness, there global analysis inner-temporal 6 old. Thinning also supero-temporal value Conclusions: model, showed thinning, possibly produced by neurodegeneration alternating with caused deposits neuroinflammation some areas retina. These over time are similar those human could be for help us better understand different during progression